Structural Biology & Biophysics Program @ Duke University

Lorena S. Beese

Structure and mechanism of proteins and macromolecular assemblies central to DNA replication, DNA repair and cellular signaling. X-ray crystallography. Structure-based drug design. Cancer biology. (website)

David Beratan

Molecular mechanisms that enable the function of complex biological machines and molecular materials (website)

Richard G Brennan

Structural and biochemical aspects of gene expression regulation, transcriptional control of multidrug resistance. X-ray crystallography. (website)

Nicolas Buchler

Molecular mechanisms and the evolution of switches and oscillators in gene networks; systems biology; comparative genomics(website)

Patrick Charbonneau

Theory and simulation of dynamical properties of self-assembly of .e.g. glasses, gels, colloids, as well as protein aggregation and crystallization.(website)

Bruce R. Donald

Algorithms in structural molecular biology and proteomics. Computational methods in biomolecular NMR. Protein design and the non-ribosomal peptide synthetase pathway. (website)

Glenn Edwards

Biological physics and Free-Electron Laser (FEL) applications (website)

Sharyn Endow

Motor mechanisms, including directionality and force production; mediation of spindle and chromosome dynamics by motors. (website)

Harold P. Erickson

Mechanism of bacterial cell division, basic principles of assembly that apply to both FtsZ and tubulin, extracellular matrix and cell adhesion (website)

Michael C. Fitzgerald

Mass spectrometry, chemical synthesis, and biophysical techniques to investigate both fundamental and practical aspects of protein folding reactions. (website)

Katherine J. Franz

The confluence of inorganic, organic and biological chemistry; esp. bioinorganic chemistry of post-translational protein modifications and the role of metal ions in neurochemistry(website)

Dan Kiehart

Biophysical approaches to cellular, molecular and developmental biology. (website)

Seok-Yong Lee

Molecular mechanism of integral membrane proteins responsible for ion transport across cell membranes using a multidisciplinary approach including X-ray crystallography, biophysics and electrophysiology. (website)

Piotr Marszalek

AFM and single-molecule biophysics. Mechanical folding of individual proteins. Applications of AFM to DNA damage and repair studies. (website)

Thomas J. McIntosh

(1) The composition, structure, and properties of membrane microdomains or "rafts", (2) the interactions between cell-lytic peptides and membranes, and (3) the use of bilayer vesicles in drug delivery. (website)

Terrence G. Oas

Protein folding; structure-function relationships of proteins; multidimensional NMR structure determination of macromolecules. (website)

David C. Richardson

Structural Bioinformatics: concepts and computer tools to visualize, analyze, and correct protein and RNA structures. (website)

Jane S. Richardson

3D structural bioinformatics of protein and RNA: structures, interactions, motions, & design; techniques for improving model accuracy. (website)

Scott C. Schmidler

Theoretical and applied research in Bayesian statistics, bioinformatics, and computational biology. (website)

Maria A Schumacher

X-ray crystallography: atomic-level understanding of key biological processes involving protein-nucleic acid interactions, especially DNA segregation. (website)

Barbara R. Shaw

Chemical reactivity of DNA; modified nucleic acids as potential antitumor and antisense agents. (website)

Leonard D. Spicer

Structure-function studies of proteins using high-field NMR techniques; physical biochemistry. (website)

Eric J. Toone

Biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. (website)

Warren Warren

Novel pulsed techniques, using controlled radiation fields to alter dynamics, usually ultrafast laser spectroscopy or nuclear magnetic resonance. (website)

Weitao Yang

Methods for quantum mechanical calculations of large systems. (website)

Kenichi Yokoyama

Enzyme Mechanisms, Radical Reactions, EPR spectroscopy, Natural Product Chemistry and Chemical Biology(website)

John D. York

The role of inositol signaling pathways in growth control and in the pharmacologic action of lithium used for the treatment of bipolar disease. (website)

Stefan Zauscher

The structure- property- performance behavior of peptide polymers, synthetic polymers, and cross-linked hydrogels. (website)

Pei Zhou

Molecular recognition and conformation variability of protein complexes in crucial biomedical processes; state-of-the-art NMR techniques. (website)